Mediated efflux of IgG molecules from brain to blood across the blood–brain barrier

@article{Zhang2001MediatedEO,
  title={Mediated efflux of IgG molecules from brain to blood across the blood–brain barrier},
  author={Y. Zhang and William M Pardridge},
  journal={Journal of Neuroimmunology},
  year={2001},
  volume={114},
  pages={168-172}
}
Dextrans and albumin exit brain from blood following intra-cerebral injection by a slow process of convection with a halftime of 10-12 h in the rat. The present studies show that immunoglobulin G (IgG) molecules rapidly efflux from brain to blood across the blood-brain barrier (BBB) following intracerebral injection. The IgG efflux is rapid with a halftime of 48 min in the rat. The efflux of [3H]mouse IgG(2a) from brain to blood is competitively inhibited by intracerebral injection of unlabeled… CONTINUE READING

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