Medial septal and nucleus basalis magnocellularis lesions produce order memory deficits in rats which mimic symptomatology of Alzheimer's disease.

@article{Kesner1986MedialSA,
  title={Medial septal and nucleus basalis magnocellularis lesions produce order memory deficits in rats which mimic symptomatology of Alzheimer's disease.},
  author={Raymond P. Kesner and Keith A. Crutcher and M O Measom},
  journal={Neurobiology of aging},
  year={1986},
  volume={7 4},
  pages={287-95}
}
Rats with electrolytic lesions of the medial septum or ibotenic acid lesions of the nucleus basalis magnocellularis (NBM) were tested in an order memory task for an 8-item list of varying spatial locations within an 8-arm radial maze. Results indicated that rats with small medial septal lesions resulting in small AchE depletion of dorsal hippocampal formation were impaired only for the first, but not the last choice orders of the list. Animals with large medial septal lesions resulting in large… CONTINUE READING