Medial prefrontal dysfunction and prolonged amygdala response during instructed fear processing in borderline personality disorder.

Abstract

OBJECTIVES Affective dysregulation is a clinical hallmark of borderline personality disorder (BPD). This study used an instructed fear task combined with functional MRI (fMRI) and skin conductance response (SCR) to test hypotheses about mechanisms of disturbed fronto-limbic neural circuitry underlying dysfunctional emotional processing in BPD. METHODS… (More)
DOI: 10.3109/15622975.2012.665174

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