Medial prefrontal cortex volume loss in rats with isolation rearing-induced deficits in prepulse inhibition of acoustic startle.

@article{DayWilson2006MedialPC,
  title={Medial prefrontal cortex volume loss in rats with isolation rearing-induced deficits in prepulse inhibition of acoustic startle.},
  author={K M Day-Wilson and Declan N. C. Jones and Eric Southam and Jackie Cilia and Susan Totterdell},
  journal={Neuroscience},
  year={2006},
  volume={141 3},
  pages={1113-21}
}
Rearing rats in isolation produces perturbations in behavior and brain neurochemistry suggested to resemble those of schizophrenia. In particular, isolation-reared rats display deficits in prepulse inhibition of acoustic startle that in humans are associated with disorders including schizophrenia and are interpreted as abnormalities in sensorimotor gating. The prefrontal cortex is considered important in the regulation of prepulse inhibition of acoustic startle and postmortem studies suggest… CONTINUE READING