Medial frontal cortex lesions selectively attenuate the hot plate response: possible nocifensive apraxia in the rat.

@article{Pastoriza1996MedialFC,
  title={Medial frontal cortex lesions selectively attenuate the hot plate response: possible nocifensive apraxia in the rat.},
  author={L N Pastoriza and Thomas J. Morrow and Kenneth L. Casey},
  journal={Pain},
  year={1996},
  volume={64 1},
  pages={11-7}
}
Lesions in the cingulate cortex have attenuated pain-related behavior in humans. We wished to evaluate an animal model of this effect by studying the effects of bilateral lesions within the medial frontal cortex, including rat cingulate cortex, on performance in 3 behavioral tests: the formalin, hot-plate, and tail-flick tests. Average hot-plate latencies, but not formalin test scores or tail-flick latencies, were significantly increased by an average of 82% in rats with medial frontal cortex… CONTINUE READING

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