Medial frontal ∼4-Hz activity in humans and rodents is attenuated in PD patients and in rodents with cortical dopamine depletion.

@article{Parker2015MedialF,
  title={Medial frontal ∼4-Hz activity in humans and rodents is attenuated in PD patients and in rodents with cortical dopamine depletion.},
  author={Krystal L Parker and Kuan-Hua Chen and Johnathan R Kingyon and James F. Cavanagh and Nandakumar S. Narayanan},
  journal={Journal of neurophysiology},
  year={2015},
  volume={114 2},
  pages={1310-20}
}
The temporal control of action is a highly conserved and critical mammalian behavior. Here, we investigate the neuronal basis of this process using an interval timing task. In rats and humans, instructional timing cues triggered spectral power across delta and theta bands (2-6 Hz) from the medial frontal cortex (MFC). Humans and rodents with dysfunctional dopamine have impaired interval timing, and we found that both humans with Parkinson's disease (PD) and rodents with local MFC dopamine… CONTINUE READING
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