Medial Temporal Lobe Activity during Source Retrieval Reflects Information Type, not Memory Strength

  title={Medial Temporal Lobe Activity during Source Retrieval Reflects Information Type, not Memory Strength},
  author={Rachel A. Diana and Andrew P. Yonelinas and Charan Ranganath},
  journal={Journal of Cognitive Neuroscience},
The medial temporal lobes (MTLs) are critical for episodic memory but the functions of MTL subregions are controversial. According to memory strength theory, MTL subregions collectively support declarative memory in a graded manner. In contrast, other theories assert that MTL subregions support functionally distinct processes. For instance, one view is that perirhinal cortex (PRc) processes item information, parahippocampal cortex (PHc) processes context information, and the hippocampus binds… 
Neural correlates of recognition memory for complex visual stimuli in the medial temporal lobe
Three experiments were designed to compare competing models of MTL function by measuring, using functional magnetic resonance imaging, the neural correlates of successful recollection- and familiarity-based memory judgements for different types of complex visual stimuli, consistent with views that the perirhinal cortex and hippocampus are differentially involved in processing objects and scenes, rather than in supporting distinct kinds of memory process.
Stimulus content and the neural correlates of source memory
Medial temporal lobe contributions to cued retrieval of items and contexts
Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval
The functional neuroimaging results suggest that the anterior and posterior hippocampus have different contributions to memory over time and that neurobiological models of memory must account for these differences.
Dissociable neural correlates of item and context retrieval in the medial temporal lobes
Dynamic Theta Networks in the Human Medial Temporal Lobe Support Episodic Memory
Prefrontal and Medial Temporal Lobe Activity at Encoding Predicts Temporal Context Memory
Evidence implicating the rostrolateral PFC in the representation of time-varying contextual states in a manner similar to that proposed by computational theories of temporal context memory is revealed.
Medial temporal lobe contributions to short-term memory for faces.
This work demonstrates that MTL amnesic patients show impaired delayed matching-to-sample (DMS) for faces in a task that meets both a traditional delay-based and a recently proposed distractor-based criterion for classification as an STM task, and provides novel evidence that the MTL supports cognition beyond the LTM domain.


Multiple routes to memory: Distinct medial temporal lobe processes build item and source memories
This work used event-related functional MRI to examine the relation between activation in distinct medial temporal lobe subregions during memory formation and the ability to later recognize an item as previously encountered and later recollect specific contextual details about the prior encounter.
Contributions of the medial temporal lobe to declarative memory retrieval: manipulating the amount of contextual retrieval.
The results suggest that the posterior parahippocampal cortex is involved in contextual retrieval on the basis of memory strength while the hippocampus processes representations of item-context binding.
Selective and Shared Contributions of the Hippocampus and Perirhinal Cortex to Episodic Item and Associative Encoding
A subsequent memory paradigm that assessed successful item encoding in addition to the encoding of two distinct episodic details, providing strong evidence for a role of the hippocampus in domain-general associative encoding and raising the possibility that PrC encoding operations in conjunction with hippocampal mechanisms contribute to later recollection of presented item details.
Item, context and relational episodic encoding in humans
  • L. Davachi
  • Psychology, Biology
    Current Opinion in Neurobiology
  • 2006
Imaging recollection and familiarity in the medial temporal lobe: a three-component model
Activity in the Medial Temporal Lobe Predicts Memory Strength, Whereas Activity in the Prefrontal Cortex Predicts Recollection
In a source memory study, a novel approach to data analysis was used that allowed item memory strength and source memory strength to be assessed independently and suggested that activity in the medial temporal lobe is predictive of subsequent memory strength, whereas activity in prefrontal cortex is predicted of subsequent recollection.
Dissociable correlates of recollection and familiarity within the medial temporal lobes
A unified framework for the functional organization of the medial temporal lobes and the phenomenology of episodic memory
Findings from physiology, functional imaging, and lesion studies in humans, monkeys, and rodents relevant to the roles of medial temporal lobe subregions in recognition memory, as well as in short‐term memory and perception are reviewed.