Mecp2 regulates neural cell differentiation by suppressing the Id1 to Her2 axis in zebrafish.

@article{Gao2015Mecp2RN,
  title={Mecp2 regulates neural cell differentiation by suppressing the Id1 to Her2 axis in zebrafish.},
  author={Hai Qing Gao and Ye Bu and Qing Wu and Xu Wang and Nannan Chang and Lei Lei and Shilin Chen and Dong Pin Liu and Xiaojun Zhu and Keping Hu and Jing-Wei Xiong},
  journal={Journal of cell science},
  year={2015},
  volume={128 12},
  pages={
          2340-50
        }
}
Rett syndrome (RTT) is a progressive neurological disorder caused by mutations in the X-linked protein methyl-CpG-binding protein 2 (MeCP2). The endogenous function of MeCP2 during neural differentiation is still unclear. Here, we report that mecp2 is required for brain development in zebrafish. Mecp2 was broadly expressed initially in embryos and enriched later in the brain. Either morpholino knockdown or genetic depletion of mecp2 inhibited neuronal differentiation, whereas its overexpression… CONTINUE READING
4
Twitter Mentions

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

Mecp2 regulates tnfa during zebrafish embryonic development and acute inflammation

  • Disease models & mechanisms
  • 2017
VIEW 4 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 75 REFERENCES

DNA methylation landscapes: provocative insights from epigenomics

  • Nature Reviews Genetics
  • 2008
VIEW 13 EXCERPTS
HIGHLY INFLUENTIAL

her11 is involved in the somitogenesis clock in zebrafish

  • Development Genes and Evolution
  • 2004
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL