Meconium Aspiration Stimulates Cyclooxygenase-2 and Nitric Oxide Synthase-2 Expression in Rat Lungs

@article{Kytl2003MeconiumAS,
  title={Meconium Aspiration Stimulates Cyclooxygenase-2 and Nitric Oxide Synthase-2 Expression in Rat Lungs},
  author={Jaakko Kyt{\"o}l{\"a} and Pekka K{\"a}{\"a}p{\"a} and Pekka Uotila},
  journal={Pediatric Research},
  year={2003},
  volume={53},
  pages={731-736}
}
To study the impact of meconium aspiration on the biosynthesis of prostaglandins and nitric oxide, we investigated the effects of intratracheal meconium instillation on the expression of cyclooxygenase-1 (COX-1) and -2 (COX-2) and endothelial (NOS-3) and inducible (NOS-2) nitric oxide synthase in rat lungs. Anesthetized, tracheotomized, and ventilated rats received 3 mL/kg human meconium suspension intratracheally (n = 19), and 14 control rats received an equal volume of saline. Ten rats were… CONTINUE READING
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