Meckelin 3 Is Necessary for Photoreceptor Outer Segment Development in Rat Meckel Syndrome

@inproceedings{Tiwari2013Meckelin3I,
  title={Meckelin 3 Is Necessary for Photoreceptor Outer Segment Development in Rat Meckel Syndrome},
  author={Sarika Tiwari and Scott E. Hudson and Vincent H. Gattone and Caroline H. Miller and Ellen A. G. Chernoff and Teri Louise Belecky-Adams},
  booktitle={PloS one},
  year={2013}
}
Ciliopathies lead to multiorgan pathologies that include renal cysts, deafness, obesity and retinal degeneration. Retinal photoreceptors have connecting cilia joining the inner and outer segment that are responsible for transport of molecules to develop and maintain the outer segment process. The present study evaluated meckelin (MKS3) expression during outer segment genesis and determined the consequences of mutant meckelin on photoreceptor development and survival in Wistar polycystic kidney… CONTINUE READING