Mechanotransduction of rat aortic vascular smooth muscle cells requires RhoA and intact actin filaments.

@article{Numaguchi1999MechanotransductionOR,
  title={Mechanotransduction of rat aortic vascular smooth muscle cells requires RhoA and intact actin filaments.},
  author={Kotaro Numaguchi and Satoru Eguchi and Tadashi Yamakawa and Evangeline D. Motley and Tadashi Inagami},
  journal={Circulation research},
  year={1999},
  volume={85 1},
  pages={5-11}
}
The growth-promoting effect of mechanical stress on vascular smooth muscle cells (VSMCs) has been implicated in the progress of vascular disease in hypertension. Extracellular signal-regulated kinases (ERKs) have been implicated in cellular responses, such as vascular remodeling, induced by mechanical stretch. However, it remains to be determined how… CONTINUE READING