Mechanotransduction at focal adhesions: integrating cytoskeletal mechanics in migrating cells

@inproceedings{Kuo2013MechanotransductionAF,
  title={Mechanotransduction at focal adhesions: integrating cytoskeletal mechanics in migrating cells},
  author={Jean-Cheng Kuo},
  booktitle={Journal of cellular and molecular medicine},
  year={2013}
}
Focal adhesions (FAs) are complex plasma membrane-associated macromolecular assemblies that serve to physically connect the actin cytoskeleton to integrins that engage with the surrounding extracellular matrix (ECM). FAs undergo maturation wherein they grow and change composition differentially to provide traction and to transduce the signals that drive cell migration, which is crucial to various biological processes, including development, wound healing and cancer metastasis. FA-related… CONTINUE READING
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Integrins and extracellular matrix in mechanotransduction

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