Mechanotransduction across the cell surface and through the cytoskeleton.

  title={Mechanotransduction across the cell surface and through the cytoskeleton.},
  author={Ning Wang and James P. Butler and Donald E. Ingber},
  volume={260 5111},
Mechanical stresses were applied directly to cell surface receptors with a magnetic twisting device. The extracellular matrix receptor, integrin beta 1, induced focal adhesion formation and supported a force-dependent stiffening response, whereas nonadhesion receptors did not. The cytoskeletal stiffness (ratio of stress to strain) increased in direct proportion to the applied stress and required intact microtubules and intermediate filaments as well as microfilaments. Tensegrity models that… CONTINUE READING
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