Mechanosensory Neurite Termination and Tiling Depend on SAX-2 and the SAX-1 Kinase

  title={Mechanosensory Neurite Termination and Tiling Depend on SAX-2 and the SAX-1 Kinase},
  author={Maria Eugenia Gallegos and Cornelia I Bargmann},
Mechanosensory neurons provide accurate information about stimulus location by restricting their sensory dendrites to nonoverlapping regions, a pattern called tiling. Here, we show that C. elegans sax-1 and sax-2 regulate mechanosensory tiling by controlling the termination point of sensory dendrites. During development, the posterior PLM mechanosensory dendrite overlaps transiently with the anterior ALM mechanosensory neuron. This overlap is eliminated during a discrete period of paused or… CONTINUE READING

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