Mechanosensitivity of the cardiac muscarinic potassium channel. A novel property conferred by Kir3.4 subunit.

@article{Ji1998MechanosensitivityOT,
  title={Mechanosensitivity of the cardiac muscarinic potassium channel. A novel property conferred by Kir3.4 subunit.},
  author={Sen Ji and S. Ahamed John and Ya Qing Lu and James N. Weiss},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 3},
  pages={
          1324-8
        }
}
Muscarinic potassium channels are heterotetramers of Kir3.1 and other Kir3 channel subunits and play major roles in regulating membrane excitability in cardiac atrial, neuronal, and neuroendocrine tissues. We report here that rabbit atrial muscarinic potassium channels are rapidly and reversibly inhibited by membrane stretch, possibly serving as a mechanoelectrical feedback pathway. To probe the molecular basis for this phenomenon, we heterologously expressed heteromeric Kir3.1/Kir3.4 channels… CONTINUE READING