Mechanosensitivity of bone cells to oscillating fluid flow induced shear stress may be modulated by chemotransport.

@article{Donahue2003MechanosensitivityOB,
  title={Mechanosensitivity of bone cells to oscillating fluid flow induced shear stress may be modulated by chemotransport.},
  author={Tammy Haut Donahue and Traci R Haut and Clare E. Yellowley and Henry J Donahue and Christopher Rae Jacobs},
  journal={Journal of biomechanics},
  year={2003},
  volume={36 9},
  pages={1363-71}
}
Fluid flow has been shown to be a potent physical stimulus in the regulation of bone cell metabolism. In addition to membrane shear stress, loading-induced fluid flow will enhance chemotransport due to convection or mass transport thereby affecting the biochemical environment surrounding the cell. This study investigated the role of oscillating fluid flow induced shear stress and chemotransport in cellular mechanotransduction mechanisms in bone. Intracellular calcium mobilization and… CONTINUE READING

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