Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels.

@article{Brohawn2014MechanosensitivityIM,
  title={Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels.},
  author={Stephen G. Brohawn and Zhenwei Su and Roderick MacKinnon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 9},
  pages={3614-9}
}
Mechanosensitive ion channels underlie neuronal responses to physical forces in the sensation of touch, hearing, and other mechanical stimuli. The fundamental basis of force transduction in eukaryotic mechanosensitive ion channels is unknown. Are mechanical forces transmitted directly from membrane to channel as in prokaryotic mechanosensors or are they mediated through macromolecular tethers attached to the channel? Here we show in cells that the K(+) channel TRAAK (K2P4.1) is responsive to… CONTINUE READING
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Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel

  • SG Brohawn, J del Mármol, R MacKinnon
  • Science
  • 2012
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