Mechanosensitive microRNA-181b Regulates Aortic Valve Endothelial Matrix Degradation by Targeting TIMP3.

@article{Heath2018MechanosensitiveMR,
  title={Mechanosensitive microRNA-181b Regulates Aortic Valve Endothelial Matrix Degradation by Targeting TIMP3.},
  author={Jack M. Heath and Joan Fern{\'a}ndez Esmerats and Lucky Khambouneheuang and Sandeep Kumar and Rachel D Simmons and Hanjoong Jo},
  journal={Cardiovascular engineering and technology},
  year={2018},
  volume={9 2},
  pages={
          141-150
        }
}
Calcific aortic valve disease (CAVD) is a major cause of morbidity in the aging population, but the underlying mechanisms of its progression remain poorly understood. Aortic valve calcification preferentially occurs on the fibrosa, which is subjected to disturbed flow. The side-specific progression of the disease is characterized by inflammation, calcific lesions, and extracellular matrix (ECM) degradation. Here, we explored the role of mechanosensitive microRNA-181b and its downstream targets… CONTINUE READING