Mechanosensitive ion channels of E. coli activated by amphipaths

@article{Martinac1990MechanosensitiveIC,
  title={Mechanosensitive ion channels of E. coli activated by amphipaths},
  author={Boris Martinac and Julius Adler and Ching Kung},
  journal={Nature},
  year={1990},
  volume={348},
  pages={261-263}
}
MECHANOSENSITIVE channels have been found in more than 30 cell types, including bacterial1,2, yeast3, plant4 and animal cells5–9. Whether tension is transferred to the channel through the lipid bilayer and/or underlying cytoskeleton is not clear. Using the patch-clamp method10, we found that amphipathic compounds, which are molecules having hydrophobic and hydrophilic character with positive, negative or no net electric charge at pH7, could slowly activate the mechanosensitive channels of giant… CONTINUE READING
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