Mechanosensitive TRPC1 channels promote calpain proteolysis of talin to regulate spinal axon outgrowth.

@article{Kerstein2013MechanosensitiveTC,
  title={Mechanosensitive TRPC1 channels promote calpain proteolysis of talin to regulate spinal axon outgrowth.},
  author={Patrick C. Kerstein and Bridget T. Jacques-Fricke and Juliana Rengifo and Brian J Mogen and Justin C Williams and Philip A Gottlieb and Fredrick Sachs and Timothy M Gomez},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 1},
  pages={
          273-85
        }
}
Intracellular Ca(2+) signals control the development and regeneration of spinal axons downstream of chemical guidance cues, but little is known about the roles of mechanical cues in axon guidance. Here we show that transient receptor potential canonical 1 (TRPC1) subunits assemble mechanosensitive (MS) channels on Xenopus neuronal growth cones that regulate the extension and direction of axon outgrowth on rigid, but not compliant, substrata. Reducing expression of TRPC1 by antisense morpholinos… CONTINUE READING

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