Mechanosensitive Kinases Regulate Stiffness-Induced Cardiomyocyte Maturation

Cells secrete and assemble extracellular matrix throughout development, giving rise to time-dependent, tissue-specific stiffness. Mimicking myocardial matrix stiffening, i.e. ~10-fold increase over 1 week, with a hydrogel system enhances myofibrillar organization of embryonic cardiomyocytes compared to static hydrogels, and thus we sought to identify… CONTINUE READING

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Averaging 7 citations per year over the last 3 years.

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