Mechanosensation through integrins: cells act locally but think globally.

@article{Ingber2003MechanosensationTI,
  title={Mechanosensation through integrins: cells act locally but think globally.},
  author={Donald E. Ingber},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 4},
  pages={1472-4}
}
  • Donald E. Ingber
  • Published 2003 in
    Proceedings of the National Academy of Sciences…
C ells sense cues that guide their growth and development by probing their microenvironment with surface membrane receptors that elicit intracellular signals when they bind their ligands. Cell interactions with extracellular matrix (ECM) molecules differ from those with soluble regulatory factors, however, because in addition to ligation-induced signaling, cells also apply traction to their integrin receptors that mediate ECM adhesion (1). Tensional forces generated in the actin cytoskeleton… CONTINUE READING

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