Mechanosensation and endothelin in astrocytes--hypothetical roles in CNS pathophysiology.

Abstract

Endothelin (ET) is a potent autocrine mitogen produced by reactive and neoplastic astrocytes. ET has been implicated in the induction of astrocyte proliferation and other transformations engendered by brain pathology, and in promoting the malignant behavior of astrocytomas. Reactive astrocytes containing ET are found in the periphery/penumbra of a wide… (More)

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@article{Ostrow2005MechanosensationAE, title={Mechanosensation and endothelin in astrocytes--hypothetical roles in CNS pathophysiology.}, author={Lyle W. Ostrow and Frederick Sachs}, journal={Brain research. Brain research reviews}, year={2005}, volume={48 3}, pages={488-508} }