Mechanoreception at the cellular level: the detection, interpretation, and diversity of responses to mechanical signals.

@article{Banes1995MechanoreceptionAT,
  title={Mechanoreception at the cellular level: the detection, interpretation, and diversity of responses to mechanical signals.},
  author={Albert Joseph Banes and Mari Tsuzaki and Junko Yamamoto and Thomas Fischer and Brian E. Brigman and Tashalee R. Brown and Lori Anne Miller},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  year={1995},
  volume={73 7-8},
  pages={349-65}
}
Cells from diverse tissues detect mechanical load signals by similar mechanisms but respond differently. The diversity of responses reflects the genotype of the cell and the mechanical demands of the resident tissue. We hypothesize that cells maintain a basal equilibrium stress state that is a function of the number and quality of focal adhesions, the polymerization state of the cytoskeleton, and the amount of extrinsic, applied mechanical deformation. A load stimulus detected by a mechano… CONTINUE READING

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