Mechanoimmunology: molecular-scale forces govern immune cell functions

@inproceedings{Pageon2018MechanoimmunologyMF,
  title={Mechanoimmunology: molecular-scale forces govern immune cell functions},
  author={Sophie V Pageon and Matt A. Govendir and Daryan Kempe and Mat{\'e} Biro},
  booktitle={Molecular biology of the cell},
  year={2018}
}
Immune cell recognition of antigens is a pivotal process in initiating immune responses against injury, pathogens, and cancers. Breakthroughs over the past decade support a major role for mechanical forces in immune responses, laying the foundation for the emerging field of mechanoimmunology. In this Perspective, we discuss the mechanical forces acting at the level of ligand-receptor interactions and how they underpin receptor triggering, signal initiation, and immune cell activation. We also… CONTINUE READING
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