Mechanoenzymatics of titin kinase.

  title={Mechanoenzymatics of titin kinase.},
  author={Elias M. Puchner and A. E. Alexandrovich and Ay Lin Kho and Ulf Hensen and Lars V. Sch{\"a}fer and Birgit D Brandmeier and Frauke Gr{\"a}ter and Helmut Grubmueller and Hermann Eduard Gaub and Mathias Gautel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={105 36},
Biological responses to mechanical stress require strain-sensing molecules, whose mechanically induced conformational changes are relayed to signaling cascades mediating changes in cell and tissue properties. In vertebrate muscle, the giant elastic protein titin is involved in strain sensing via its C-terminal kinase domain (TK) at the sarcomeric M-band and contributes to the adaptation of muscle in response to changes in mechanical strain. TK is regulated in a unique dual autoinhibition… CONTINUE READING


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