Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins.

  title={Mechanoelectrical feedback regulates the arrhythmogenic activity of pulmonary veins.},
  author={S-L Chang and Yee-Chun Chen and Yen-Jen Chen and Wiwat Wangcharoen and Sang-Hee Lee and C-I Lin and Shiqi Chen},
  volume={93 1},
BACKGROUND Atrial fibrillation is commonly associated with dilated pulmonary veins. Stretch has been shown to have mechano-electrical effects. OBJECTIVE To investigate whether stretch can increase the arrhythmogenic activity of the pulmonary veins. METHODS The transmembrane action potentials were recorded from rabbit pulmonary veins before and after stretch (100 and 300 mg). Gadolinium and streptomycin (stretch-activated ion channel blockers) were each perfused into the pulmonary veins… CONTINUE READING

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