Mechanoelectrical excitation by fluid jets in monolayers of cultured cardiac myocytes.

@article{Kong2005MechanoelectricalEB,
  title={Mechanoelectrical excitation by fluid jets in monolayers of cultured cardiac myocytes.},
  author={Chae-Ryon Kong and Nenad Bursac and Leslie Tung},
  journal={Journal of applied physiology},
  year={2005},
  volume={98 6},
  pages={
          2328-36; discussion 2320
        }
}
Although the prevailing view of mechanoelectric feedback (MEF) in the heart is in terms of longitudinal cell stretch, other mechanical forces are considerable during the cardiac cycle, including intramyocardial pressure and shear stress. Their contribution to MEF is largely unknown. In this study, mechanical stimuli in the form of localized fluid jet pulses were applied to neonatal rat ventricular cells cultured as confluent monolayers. Such pulses result in pressure and shear stresses (but not… CONTINUE READING
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