Mechanochemical regulation of growth cone motility

@inproceedings{Kerstein2015MechanochemicalRO,
  title={Mechanochemical regulation of growth cone motility},
  author={Patrick C. Kerstein and IV RobertH.Nichol and Timothy M Gomez},
  booktitle={Front. Cell. Neurosci.},
  year={2015}
}
Neuronal growth cones are exquisite sensory-motor machines capable of transducing features contacted in their local extracellular environment into guided process extension during development. Extensive research has shown that chemical ligands activate cell surface receptors on growth cones leading to intracellular signals that direct cytoskeletal changes. However, the environment also provides mechanical support for growth cone adhesion and traction forces that stabilize leading edge… CONTINUE READING

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