Mechano-transduction in periodontal ligament cells identifies activated states of MAP-kinases p42/44 and p38-stress kinase as a mechanism for MMP-13 expression

@inproceedings{Ziegler2009MechanotransductionIP,
  title={Mechano-transduction in periodontal ligament cells identifies activated states of MAP-kinases p42/44 and p38-stress kinase as a mechanism for MMP-13 expression},
  author={Nelli Ziegler and Angel Alonso and Thorsten Steinberg and D. A. Woodnutt and Annette Kohl and Eva M{\"u}ssig and Simon Daniel Schulz and Pascal Tomakidi},
  booktitle={BMC Cell Biology},
  year={2009}
}
Mechano-transduction in periodontal ligament (PDL) cells is crucial for physiological and orthodontic tooth movement-associated periodontal remodelling. On the mechanistic level, molecules involved in this mechano-transduction process in PDL cells are not yet completely elucidated. In the present study we show by western blot (WB) analysis and/or indirect immunofluorescence (IIF) that mechanical strain modulates the amount of the matrix metalloproteinase MMP-13, and induces non-coherent… CONTINUE READING

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