Mechano-growth factor reduces loss of cardiac function in acute myocardial infarction.

  title={Mechano-growth factor reduces loss of cardiac function in acute myocardial infarction.},
  author={Violaine Carpenter and Kenneth E. Matthews and Gerard Devlin and Selwyn P Stuart and J Ingemann Jensen and John V. Conaglen and Ferenc Jeanplong and Paul H. Goldspink and Shi-yu Yang and Geoffrey Goldspink and James Bass and Christopher J McMahon},
  journal={Heart, lung & circulation},
  volume={17 1},
BACKGROUND Mechano-growth factor (MGF) is a splice-variant of IGF-I sharing an identical mature region, but with a different E domain. Our objective was to determine if MGF would reduce the area of 'at-risk' myocardium and improve cardiac function in the post-infarct heart. METHODS Infarcts were induced by injection of microspheres. In experiment 1, sheep were treated with vehicle, 200 nM each of mature IGF-I, MGF E domain, or full-length MGF. In experiment 2, sheep were treated with vehicle… CONTINUE READING


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