Mechano growth factor, a splice variant of IGF-1, promotes neurogenesis in the aging mouse brain

Abstract

Mechano growth factor (MGF) is a splice variant of IGF-1 first described in skeletal muscle. MGF induces muscle cell proliferation in response to muscle stress and injury. In control mice we found endogenous expression of MGF in neurogenic areas of the brain and these levels declined with age. To better understand the role of MGF in the brain, we used… (More)
DOI: 10.1186/s13041-017-0304-0

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