Mechano-Coupling and Regulation of Contractility by the Vinculin Tail Domain

@article{Mierke2008MechanoCouplingAR,
  title={Mechano-Coupling and Regulation of Contractility by the Vinculin Tail Domain},
  author={Claudia Tanja Mierke and Philip Kollmannsberger and Daniel Paranhos Zitterbart and James Thomas Smith and Ben Fabry and Wolfgang Heinrich Goldmann},
  journal={Biophysical Journal},
  year={2008},
  volume={94},
  pages={661 - 670}
}
Vinculin binds to multiple focal adhesion and cytoskeletal proteins and has been implicated in transmitting mechanical forces between the actin cytoskeleton and integrins or cadherins. It remains unclear to what extent the mechano-coupling function of vinculin also involves signaling mechanisms. We report the effect of vinculin and its head and tail domains on force transfer across cell adhesions and the generation of contractile forces. The creep modulus and the adhesion forces of F9 mouse… CONTINUE READING

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