Mechanistic understanding of the different effects of Wuzhi Tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of Tacrolimus (FK506).

@article{Qin2010MechanisticUO,
  title={Mechanistic understanding of the different effects of Wuzhi Tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of Tacrolimus (FK506).},
  author={Xiao Ling Qin and Hui Chang Bi and Xue Ding Wang and Jia Li Li and Ying Wang and Xin Ping Xue and Xiao Chen and Chang Xi Wang and Le Jia Xu and Yi Tao Wang and Min Huang},
  journal={International journal of pharmaceutics},
  year={2010},
  volume={389 1-2},
  pages={114-21}
}
We recently reported that the blood concentrations of Tacrolimus (FK506) in rats were markedly increased following the intake of a Chinese herbal preparation, Wuzhi Tablet (WZ, Schisandra sphenanthera extract). In order to identify the underlying mechanisms of the increase in FK506 level, we investigated the effects of WZ on the absorption and first-pass intestinal and hepatic metabolism of FK506 in vitro and in vivo. When co-administered with WZ, the AUC(0-infinity) value after oral FK506… CONTINUE READING

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