Mechanistic understanding of N-glycosylation in Ebola virus glycoprotein maturation and function.


The Ebola virus (EBOV) trimeric envelope glycoprotein (GP) precursors are cleaved into the receptor-binding GP1 and the fusion-mediating GP2 subunits and incorporated into virions to initiate infection. GP1 and GP2 form heterodimers that have 15 or two N-glycosylation sites (NGSs), respectively. Here we investigated the mechanism of how N-glycosylation… (More)
DOI: 10.1074/jbc.M116.768168