Mechanistic target of rapamycin activation triggers IL-4 production and necrotic death of double-negative T cells in patients with systemic lupus erythematosus.

@article{Lai2013MechanisticTO,
  title={Mechanistic target of rapamycin activation triggers IL-4 production and necrotic death of double-negative T cells in patients with systemic lupus erythematosus.},
  author={Zhi-wei Lai and Rebecca Borsuk and Ashwini Shadakshari and Jianghong Yu and Maha Dawood and Ricardo J Garcia and Lisa Francis and Hajra Ismail Tily and Adam Bartos and Stephen V Faraone and Paul E. Phillips and Andr{\'a}s Perl},
  journal={Journal of immunology},
  year={2013},
  volume={191 5},
  pages={2236-46}
}
The mechanistic target of rapamycin (mTOR) is recognized as a sensor of mitochondrial dysfunction and effector of T cell lineage development; however, its role in autoimmunity, including systemic lupus erythematosus, remains unclear. In this study, we prospectively evaluated mitochondrial dysfunction and mTOR activation in PBLs relative to the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) during 274 visits of 59 patients and 54 matched healthy subjects. Partial least square… CONTINUE READING
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