Mechanistic studies on the monoamine oxidase B catalyzed oxidation of 1,4-disubstituted tetrahydropyridines.

Abstract

Previous studies have established that 1-cyclopropyl-4-phenyl-1,2,3,6- tetrahydropyridine (6) is an efficient time and concentration dependent inhibitor of the flavin containing enzyme monoamine oxidase B (MAO-B). This behavior is consistent with a proposed mechanism based inactivation pathway initiated by transfer of one of the nitrogen nonbonding pairs of… (More)

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@article{Kuttab1994MechanisticSO, title={Mechanistic studies on the monoamine oxidase B catalyzed oxidation of 1,4-disubstituted tetrahydropyridines.}, author={Simon Kuttab and Amit S. Kalgutkar and Neal Castagnoli}, journal={Chemical research in toxicology}, year={1994}, volume={7 6}, pages={740-4} }