Mechanistic studies on the bioactivation of diclofenac: identification of diclofenac-S-acyl-glutathione in vitro in incubations with rat and human hepatocytes.

Abstract

Diclofenac, a nonsteroidal anti-inflammatory drug, is metabolized to diclofenac-1-O-acyl glucuronide (D-1-O-G), a chemically reactive conjugate that has been implicated as playing a role in the idiosyncratic hepatoxicity associated with its use. The present studies investigated the ability of diclofenac to be metabolized to diclofenac-S-acyl-glutathione… (More)

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@article{Grillo2003MechanisticSO, title={Mechanistic studies on the bioactivation of diclofenac: identification of diclofenac-S-acyl-glutathione in vitro in incubations with rat and human hepatocytes.}, author={Mark P. Grillo and Fengmei Hua and Charles G. Knutson and J. Anthony Ware and Chunze Li}, journal={Chemical research in toxicology}, year={2003}, volume={16 11}, pages={1410-7} }