Mechanistic studies on bovine cytosolic 5'-nucleotidase II, an enzyme belonging to the HAD superfamily.

@article{Allegrini2004MechanisticSO,
  title={Mechanistic studies on bovine cytosolic 5'-nucleotidase II, an enzyme belonging to the HAD superfamily.},
  author={Simone Allegrini and Andrea Scaloni and Maria Giovanna Careddu and Giovanna Cuccu and Chiara D'Ambrosio and Rossana Pesi and Marcella Camici and Lino Ferrara and Maria Grazia Tozzi},
  journal={European journal of biochemistry},
  year={2004},
  volume={271 23-24},
  pages={4881-91}
}
Cytosolic 5'-nucleotidase/phosphotransferase specific for 6-hydroxypurine monophosphate derivatives (cN-II), belongs to a class of phosphohydrolases that act through the formation of an enzyme-phosphate intermediate. Sequence alignment with members of the P-type ATPases/L-2-haloacid dehalogenase superfamily identified three highly conserved motifs in cN-II and other cytosolic nucleotidases. Mutagenesis studies at specific amino acids occurring in cN-II conserved motifs were performed. The… CONTINUE READING
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