Mechanistic studies of peptide self-assembly: transient α-helices to stable β-sheets.

Abstract

The pathologic self-assembly of proteins is associated with typically late-onset disorders such as Alzheimer's disease, Parkinson's disease, and type 2 diabetes. Important mechanistic details of the self-assembly are unknown, but there is increasing evidence supporting the role of transient α-helices in the early events. Islet amyloid polypeptide (IAPP) is… (More)
DOI: 10.1021/ja1069882

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