Mechanistic studies of initiator-initiator interaction and replication initiation.

  title={Mechanistic studies of initiator-initiator interaction and replication initiation.},
  author={Yun Biao Lu and Hirock Jyoti Datta and Deepak Bastia},
  journal={The EMBO journal},
  volume={17 17},
Unlike the chromosome of Escherichia coli that needs only one replication initiator protein (origin recognition protein) called DnaA, many plasmid replicons require dual initiators: host-encoded DnaA and a plasmid-encoded origin recognition protein, which is believed to be the major determinant of replication control. Hitherto, the relative mechanistic roles of dual initiators in DNA replication were unclear. Here, we present the first evidence that DnaA communicates with the plasmid-encoded pi… CONTINUE READING


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