Mechanistic simulations of inflammation: current state and future prospects.

  title={Mechanistic simulations of inflammation: current state and future prospects.},
  author={Yoram Vodovotz and G. M. Constantine and Jonathan Rubin and M{\'a}rie Csete and Eberhard O. Voit and Gary An},
  journal={Mathematical biosciences},
  volume={217 1},
Inflammation is a normal, robust physiological process. It can also be viewed as a complex system that senses and attempts to resolve homeostatic perturbations initiated from within the body (for example, in autoimmune disease) or from the outside (for example, in infections). Virtually all acute and chronic diseases are either driven or modulated by inflammation. The complex interplay between beneficial and harmful arms of the inflammatory response may underlie the lack of fully effective… CONTINUE READING