Mechanistic simulation of normal-tissue damage in radiotherapy—implications for dose–volume analyses

  title={Mechanistic simulation of normal-tissue damage in radiotherapy—implications for dose–volume analyses},
  author={Eva Rutkowska and Colin R. Baker and Alan Effraim Nahum},
  journal={Physics in Medicine \& Biology},
  pages={2121 - 2136}
A radiobiologically based 3D model of normal tissue has been developed in which complications are generated when ‘irradiated’. The aim is to provide insight into the connection between dose-distribution characteristics, different organ architectures and complication rates beyond that obtainable with simple DVH-based analytical NTCP models. In this model the organ consists of a large number of functional subunits (FSUs), populated by stem cells which are killed according to the LQ model. A… 
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