# Mechanistic simulation of normal-tissue damage in radiotherapy—implications for dose–volume analyses

@article{Rutkowska2010MechanisticSO, title={Mechanistic simulation of normal-tissue damage in radiotherapy—implications for dose–volume analyses}, author={Eva Rutkowska and Colin R. Baker and Alan Effraim Nahum}, journal={Physics in Medicine \& Biology}, year={2010}, volume={55}, pages={2121 - 2136} }

A radiobiologically based 3D model of normal tissue has been developed in which complications are generated when ‘irradiated’. The aim is to provide insight into the connection between dose-distribution characteristics, different organ architectures and complication rates beyond that obtainable with simple DVH-based analytical NTCP models. In this model the organ consists of a large number of functional subunits (FSUs), populated by stem cells which are killed according to the LQ model. A…

## 29 Citations

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The clinical impact of the differences in absolute doses calculated by various photon dose calculation algorithms for two clinical tumour sites was investigated and the tumour control probability (TCP) and normal tissue complication probability (N TCP) were estimated using well established bio-mathematical radiobiological models.

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- MedicineMedical physics
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This work shows that identifying confounding factors, and developing methods to quantify them, is more important than the choice of NTCP model.

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The model is based on the dynamics of proliferative and functional cells populations in irradiated mucosa, and incorporates the three A's: Accelerated proliferation, loss of Asymmetric proliferation, Abortive divisions and could prove helpful when designing unconventional dose fractionations, schedules not covered by datasets to which phenomenological models of toxicity have been fitted.

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Developing multi-compartment mechanistic models of dynamics of stem and functional cell populations in epithelium after irradiation can facilitate the development of mucositis response models to nonstandard schedules/treatment combinations not covered by datasets to which phenomenological models have been fitted.

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- Medicine, Physics
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Dose ranges providing significant cut-points tended to be consistent with those showing significant univariate regression odds-ratios (representing the probability of a unitary increase in toxicity grade per percent relative volume), which validated previously published results.

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- MedicineInternational journal of radiation oncology, biology, physics
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Normal tissue complication probability (NTCP) models for modern radiation therapy.

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Issues relevant to hypofractionated stereotactic body RT and ion beam therapy are critically reviewed and a new phenomenological approach to predict RIM is suggested.

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