Mechanistic signs of double-barreled structure in a fluoride ion channel

@inproceedings{Last2016MechanisticSO,
  title={Mechanistic signs of double-barreled structure in a fluoride ion channel},
  author={Nicholas B. Last and Ludmila Kolmakova-Partensky and Tierling Shane and Christopher Miller},
  booktitle={eLife},
  year={2016}
}
The Fluc family of F(-) ion channels protects prokaryotes and lower eukaryotes from the toxicity of environmental F(-). In bacteria, these channels are built as dual-topology dimers whereby the two subunits assemble in antiparallel transmembrane orientation. Recent crystal structures suggested that Fluc channels contain two separate ion-conduction pathways, each with two F(-) binding sites, but no functional correlates of this unusual architecture have been reported. Experiments here fill this… CONTINUE READING
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