Mechanistic role of an NS4A peptide cofactor with the truncated NS3 protease of hepatitis C virus: elucidation of the NS4A stimulatory effect via kinetic analysis and inhibitor mapping.

@article{Landro1997MechanisticRO,
  title={Mechanistic role of an NS4A peptide cofactor with the truncated NS3 protease of hepatitis C virus: elucidation of the NS4A stimulatory effect via kinetic analysis and inhibitor mapping.},
  author={James A Landro and Scott A. Raybuck and Y P Luong and Ethan T O'Malley and Scott L Harbeson and Kurt A Morgenstern and Guohua Rao and David J. Livingston},
  journal={Biochemistry},
  year={1997},
  volume={36 31},
  pages={9340-8}
}
Infection by hepatitis C viruses (HCVs) is a serious medical problem with no broadly effective treatment available for the progression of chronic hepatitis. The catalytic activity of a viral serine protease located in the N-terminal one-third of nonstructural protein 3 (NS3) is required for polyprotein processing at four site-specific junctions. The three-dimensional crystal structure of the NS3-NS4A co-complex [Kim, J. L., Morgenstern, K. A., Lin, C., Fox, T., Dwyer, M. D., Landro, J. A… CONTINUE READING
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