Mechanistic peptidomics: factors that dictate specificity in the formation of endogenous peptides in human milk.

@article{Guerrero2014MechanisticPF,
  title={Mechanistic peptidomics: factors that dictate specificity in the formation of endogenous peptides in human milk.},
  author={Andr{\'e}s N Guerrero and David C. Dallas and Stephanie C Contreras and Sabrina Chee and Evan Parker and Xin Sun and Lauren M Dimapasoc and Daniela Barile and J. Bruce German and Carlito B. Lebrilla},
  journal={Molecular & cellular proteomics : MCP},
  year={2014},
  volume={13 12},
  pages={3343-51}
}
An extensive mass spectrometry analysis of the human milk peptidome has revealed almost 700 endogenous peptides from 30 different proteins. Two in-house computational tools were created and used to visualize and interpret the data through both alignment of the peptide quasi-molecular ion intensities and estimation of the differential enzyme participation. These results reveal that the endogenous proteolytic activity in the mammary gland is remarkably specific and well conserved. Certain… CONTINUE READING

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