Mechanistic modelling of drug release from multi-layer capsules

@article{Kaoui2018MechanisticMO,
  title={Mechanistic modelling of drug release from multi-layer capsules},
  author={Badr Kaoui and Marco Lauricella and Giuseppe Pontrelli},
  journal={Computers in biology and medicine},
  year={2018},
  volume={93},
  pages={
          149-157
        }
}
We propose a novel in silico model for computing drug release from multi-layer capsules. The diffusion problem in such heterogeneous layer-by-layer composite medium is described by a system of coupled partial differential equations, which we solve analytically using separation of variables. In addition to the conventional partitioning and mass transfer interlayer conditions, we consider a surface finite mass transfer resistance, which corresponds to the case of a coated capsule. The drug… CONTINUE READING

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