Mechanistic modelling in large case-control studies of lung cancer risk from smoking.

@article{Heidenreich2002MechanisticMI,
  title={Mechanistic modelling in large case-control studies of lung cancer risk from smoking.},
  author={W. F. Heidenreich and Juergen Wellmann and P. Philip Jacob and H Erich Wichmann},
  journal={Statistics in medicine},
  year={2002},
  volume={21 20},
  pages={3055-70}
}
The two-step clonal expansion (TSCE) model is applied to large case-control studies, frequency matched for age, which allow estimation of the RR of lung tumour risk caused by smoking. For estimating background hazard rates, mortality data from the study areas are used to supplement the case-control data. Two approaches are used to analyse the data, based on the unconditional and the conditional likelihoods. They are demonstrated to give nearly identical results. Some model diagnostics are… CONTINUE READING
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