Mechanistic modeling of hepatic transport from cells to whole body: application to napsagatran and fexofenadine.

@article{Poirier2009MechanisticMO,
  title={Mechanistic modeling of hepatic transport from cells to whole body: application to napsagatran and fexofenadine.},
  author={Agn{\'e}s Poirier and Christoph Funk and J. -M. Scherrmann and Thierry Lav{\'e}},
  journal={Molecular pharmaceutics},
  year={2009},
  volume={6 6},
  pages={1716-33}
}
A mechanistic model was applied to quantitatively derive the kinetic parameters from in vitro hepatic uptake transport data. These parameters were used as input to simulate in vivo elimination using a fully mechanistic physiologically based pharmacokinetic (PBPK) model. Fexofenadine and napsagatran, both BDDCS class 3 drugs, were chosen as model compounds. In rat, both compounds are hardly metabolized and are eliminated unchanged mostly through biliary excretion. Uptake was estimated in this… CONTINUE READING

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