Mechanistic investigation of the stimulus properties of 1-(3-trifluoromethylphenyl)piperazine.

  title={Mechanistic investigation of the stimulus properties of 1-(3-trifluoromethylphenyl)piperazine.},
  author={J L Herndon and M. Edward Pierson and Richard A Glennon},
  journal={Pharmacology, biochemistry, and behavior},
  volume={43 3},
Using a standard two-lever operant procedure with rats trained to discriminate 1-(3-trifluoromethylphenyl)piperazine (TFMPP) (0.5 mg/kg) from saline, tests of stimulus antagonism and stimulus generalization were performed to better understand the stimulus properties of this agent. The agents examined for ability to antagonize the TFMPP stimulus were prazosin, quipazine, zacopride, buspirone, 8-hydroxy-2-(di-N-propylamino) tetralin (8-OH-DPAT), 1-(2-methoxyphenol)-4-[4-(2-phthalimido)butyl… CONTINUE READING
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